Mitochondrial dysfunction driven by the LRRK2-mediated pathway is associated with loss of Purkinje cells
and motor coordination deficits in diabetic rat model.
In a 2012 mouse study, Sahin and colleagues knocked out a TSC gene (Tsc1) in Purkinje cells
and found social deficits and repetitive behaviors in the mice, together with abnormalities in the cells.
Keywords: Electromagnetic field (EMF), Fourth generation (4G) mobile phones, Purkinje cell
layer, Rats, Second generation (2G), Third generation (3G) mobile phones.
A variety of studies have shown that [alpha]-synuclein accumulates in Purkinje cells
during various neurodegenerative diseases like PD and LBD [20, 21].
During wrist movement, Purkinje cells
(PCs) with somatosensory receptive fields (RFs) in the distal arm are strongly suppressed before movement onset, while DNs with the same RFs show concurrent bursts of activity (disinhibitory control on DNs).
The Purkinje cells
(PC) appear arranged in one row at day 7 and become more developed and mature at day 15 and day 30.
Most of the Purkinje cells
in cerebellar cortex appeared deformed and shrunken loosing their characteristic pyriform shape after two week .
The most reasonable mechanism is a local hypertrophy of granular cell neurons after migrating more or less completely from the subpial layer, as a compensatory response following degeneration of other neurons or of purkinje cells
. Another postulate suggested that the localized disappearance of purkinje cells
is secondary to tissue compression due to hypertrophy of granular cell neurons.
deficits in nonhuman primates following weekly exposure to ethanol during gestation.
The objective of this study was to evaluate the effects of a low dose (1/5 DL50) of cypermethrin on the cerebellar cortex, focusing on the density of the Purkinje cell
population and the expression of apoptotic (Apaf-1) and proliferation (Ki67) biomarkers, as regulators of cellular proliferation processes, through the route of caspases and cell cycle regulatory factors, respectively.
Unlike the cerebellar granule cells, purkinje cells
are all generated before birth on E13 to E16, (13) and Purkinje cell
dendritic outgrowth and synaptogenesis occur during postnatal three weeks.