Previous brain autopsies have shown that patients with TSC, as well as patients with ASD, have reduced numbers of Purkinje cells
, the main type of neuron that communicates out of the cerebellum.
Keywords: Electromagnetic field (EMF), Fourth generation (4G) mobile phones, Purkinje cell
layer, Rats, Second generation (2G), Third generation (3G) mobile phones.
1996) Loss of cerebellar Purkinje cells
in aged mice homozygous for a disrupted PrP gene.
Studies have found that binge ethanol exposure in all three trimesters leads to deficits in fetal cerebellar Purkinje cells
(Ramadoss et al.
This implies that an alteration on the GABA receptors can affect the cerebellar circuits and the cerebellar cell population, which can induce a decrease in the Purkinje cell
population, as observed in the present study.
Unlike the cerebellar granule cells, purkinje cells
are all generated before birth on E13 to E16, (13) and Purkinje cell
dendritic outgrowth and synaptogenesis occur during postnatal three weeks.
Only 4% showed nervous lesion in the brain such as neuronal and Purkinje cell
necrosis of cerebrum and cerebellum, respectively.
Even though significant cerebellar Purkinje cell
loss remained following early alcohol exposure, an increase in the number of synaptic connections for each of the remaining Purkinje cells
was found, showing the capacity for synaptic plasticity (Klintsova et al.
2004) Microglia promote the death of developing Purkinje cells
Armengol, "Naturally occurring neuronal death during the postnatal development of Purkinje cells
and their precerebellar afferent projections," Brain Research Reviews, vol.
Arthropod-borne diseases, such as loupingill in sheep and Russian tick-borne encephalitis in dogs and horses, share the features of neurotropism, Purkinje cell
necrosis, and a similar anatomic distribution with BoAstV-NeuroS1 infection.
The Purkinje cell
bodies are arranged in a sheet, one cell thick at the interface of the molecular and granular layers.