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Anderson, "Distribution of purkinje fibers in the sheep heart," Anatomical Record, vol.
They were located in the loose connective tissue that was situated between the lining endothelium and Purkinje fibers. In the human heart, the subendocardial lymphatic capillaries are less pronounced.
Drugs, including antiarrhythmic drugs that prolong repolarization, do not uniformly prolong repolarization in all three layers of myocardium and Purkinje fibers, resulting in heterogeneity of repolarization.
Purkinje published his discovery of a part of the heart conduction system, nowadays called Purkinje fibers or Purkinje cardiomyocytes [1].
Major arrhythmias caused by chronic chloroquine use have been related to a significant reduction in the cardiac rate, increases in the action potential duration and refractory period of Purkinje fibers (7).