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QUADRUPLICATION, pleading. Formerly this word was used instead of surrebutter. 1 Bro. Civ. Law, 469, n.

A Law Dictionary, Adapted to the Constitution and Laws of the United States. By John Bouvier. Published 1856.
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More than 95% of [alpha]-thalassemia phenotypes result from meiotic unequal recombinational events between the highly homologous [alpha]1- and [alpha]2-globin loci, which lead mainly to large genomic deletions (3-100 kb), which remove one to four [alpha]-globin genes, and rarely to [alpha]-gene triplication or quadruplication. Although less frequent, at least 48 different nondeletional mutations (including point mutations and deletions/insertions of a few nucleotides), mostly located in the [alpha]2-globin gene, have also been reported as causative mutations of [[alpha].sup.+]-thalassemia (3, 4).
The triplication (actually, quadruplication) of function XV is the key to the entire sequence, but a Proppian analysis cannot reflect this.