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MUTATION, French law. This term is synonymous with change, and is particularly applied to designate the change which takes place in the property of a thing in its transmission from one person to another; permutation therefore happens when, the owner of the thing sells, exchanges or gives it. It is nearly synonymous with transfer. (q.v.) Merl. Repert. h.t.

A Law Dictionary, Adapted to the Constitution and Laws of the United States. By John Bouvier. Published 1856.
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In Drosophila melanogaster about n = 5000 loci produce recessive lethal mutations with an average mutation rate per generation of [Mathematical Expression Omitted] (Simmons and Crow 1977), giving a (diploid) genomic lethal mutation rate of U = 0.02 per generation.
"We don't yet understand why the number of recessive lethal mutations might be relatively constant across distantly related organisms," said Gao.
Selection is multiplicative across loci, so that a genotype with i heterozygous recessive lethal mutations has a relative fitness of [Mathematical Expression Omitted], where h is the dominance coefficient and the mean fitness in the population.