We are also conducting a research programme to produce larger volumes of red blood cells
The team showed that the gene-edited cells, infused back into the bloodstream, engrafted in the bone marrow and produced genetically corrected red blood cells
Sickle cell disease symptoms are caused by a shortage of good functioning red blood cells
, which causes anaemia, blood clotting and blockage of blood vessels.
To probe how red blood cells
interact with blood vessels to set off a vaso-occlusive crisis, the researchers built a specialised microfluidic system that mimics the post-capillary vessels, which carried deoxygenated blood away from the capillaries.
When this protein is absent from the red blood cells
, the cells are resistant to infection by the malaria parasite.
(8.) Zimrin AB, Hess JR (2009) Current issues relating to the transfusion of stored red blood cells
. Vox Sang 96: 93-103.
As in chronic transfusion therapy red blood cells
are transfused, so there are chances of transfusion reactions such as fever, allergy and transfusion related lung injury, etc.
"We have performed this experiment on mice, and the preliminary results indicate that it is also possible to reprogramme skin cells from humans into red blood cells
, Johan Flygare, who is also from Lund University, noted.
This leads to a shortage of red blood cells
, known as anaemia.
Too few red blood cells
in circulation may indicate anemia from blood loss or their inadequate production.
Locking malaria inside red blood cells
may prevent mosquitoes from spreading the disease from person to person, and researchers may now know which key to throw away.
Abstract: The aim of this study is to automate the counting process of Red Blood Cells
in thin Blood smear images in more accurate efficient and universal way.