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Moreover, here for the first time, a complete and long lasting protection from the lethal effect induced by a toxic type 2 ribosome-inactivating protein has been obtained by combining the caspase inhibitor Z-VAD, to either the hydrogen peroxide scavenger catalase or the necroptotic inhibitor necrostatin-1.
Berger, "Plant ribosome-inactivating proteins type II induce the unfolded protein response in human cancer cells," Cellular and Molecular Life Sciences, vol.
Molecular characterization of the recombinant A-chain of a type 11 ribosome-inactivating protein (RIP) from Viscum album coloratum and structural basis on its ribosome-inactivating activity and the sugar-binding properties of the B-chain.
1995, 1996), antifungal (Lam and Ng 2001; Wang and Ng 2004a) and HIV-1 reverse transcriptase inhibitory (Lam and Ng 2001; Wang and Ng 2001 a) activities have been purified and characterized from mushrooms including laccases (Wang and Ng 2004b), antifungal proteins (Lam and Ng 2001; Wang and Ng 2004c), ribonucleases, ribosome-inactivating proteins (Wang and Ng 2000a, 2001b), ubiquitin-like peptides (Wang et al.
Four major lectin families, namely, the legume lectins, the chitin-binding lectins composed of hevein domains, the type2 ribosome-inactivating proteins and the monocot mannose-binding lectins comprise the majority of all currently known plant lectins (Van Damme et al., 1998a).
Ribosome-Inactivating Proteins: Ricin and Related Proteins