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Researchers at Penn State College of Medicine studied a chicken virus called Rous sarcoma virus that causes cancer in chickens and is similar to HIV.
AS liquid extract was injected at the site of tumor transplantation on Day 1 for three weeks (Experiment I) and into the established tumors weekly for five weeks (Experiment II) in combination with or without gene therapy using a replication-defective adenoviral vector containing a herpes simplex virus thymidine kinase (HSV-TK) gene under the transcriptional control of Rous sarcoma virus (RSV) promoter (Ad-RSV-TK, 5 x 10(8) plaque-forming units) plus ganciclovir (20 mg/kg/day i.
Rous sarcoma virus (RSV), which Rous (1911) first described as being responsible for tumor growth in chickens, is an oncogenic retrovirus.