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Our team showed that SOCS1 is a direct regulator of the p53 gene and that in its absence the p53 pathway is significantly disabled," said Ferbeyre, noting the p53 gene is frequently lost in human cancer patients as it is SOCS1.
035 SF3B1 Carcinoma Mutation SOCS1 Carcinoma Altered gene expression (higher in some cancers, while lower in others), not well understood SYK T-cell Translocation for T- 7-fold increased lymphoma- cell lymphoma; risk in some positive heritable single- breast cancer carcinoma nucleotide populations polymorphism for increased risk in breast cancer SYK Carcinoma Translocation for T- 7-fold increased cell lymphoma; risk in some heritable single- breast cancer nucleotide populations polymorphisms for increased risk in breast cancer TLR4 Carcinoma Mutation Rare, ER-positive, HER2/neu- negative TNFAIP3 Carcinoma Overexpression TP53 Carcinoma Mutation Constitutional, 27%/ 37% (80% basal, 74% HER2/neu enriched) No.
Interaction between Ebola virus glycoprotein and host toll-like receptor 4 leads to induction of proinflammatory cytokines and SOCS1.