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The report provides a snapshot of the global therapeutic landscape for Plasminogen Activator Inhibitor-1 (Endothelial Plasminogen Activator Inhibitor or Serpin E1 or PAI-1)
Temmel, "The C-terminal 26-residue peptide of serpin A1 stimulates proliferation of breast and liver cancer cells: role of protein kinase C and CD47," FEBS Letters, vol.
In addition, TAAs may belong to a variety of protein families that are structurally and functionally distinct such as SERPINs [6].
Whisstock, 1845-1894, 2000, Phylogeny of the serpin superfamily: implication of patterns of amino acid conservation for structure and function, 10 (12).
IWANAGA (1994): <<A Limulus intracellular coagulation inhibitor with characteristics of the serpin superfamily.
AAT, FCG, and Serpin showed approximately 2 fold increase in ACS and UA samples as compared to controls at 6-12h.
The critical role of Glu-192 in restricting the reactivity of thrombin with the serpin, [[alpha].
Thrombin, its receptor and protease nexin I, its potent serpin, in the nervous system.
Antithrombin (AT) is a single-chain serpin glycoprotein that acts as a key regulator of clotting through its inhibitory effect on thrombin and factor Xa (1).
Lawrence, "The serpin PAI-1 inhibits cell migration by blocking integrin binding to vitronectin," Nature, vol.