His somatic stem cells
offer a way out of this dilemma: they are "only" multipotent, which means that they cannot give rise to all cell types but merely to a select subset of them - in this case, a type of cell found in neural tissue - a property, which affords them an edge in terms of their therapeutic potential.
Drug candidate substances ('seeds') identified through Stelic's unique theory of somatic stem cell
therapeutic concepts, which arose from a clinical setting and have been demonstrated in our laboratories, are covered by patents.
The team did several experiments to be sure that the hub cells were involved, including one in which they genetically marked the hub cells and saw the mark appear in the newly formed somatic stem cells
- a clear sign that hub cells had divided to make new stem cells.
Besides iPS cells, PERFLOW Sort is also expected to contribute to the frontier researches for regenerative medicine and drug discovery using other living cells with the potential of differentiation induction such as ES cells, somatic stem cells
and cancer stem cells.
Citation: "Conversion of Quiescent Niche Cells to Somatic Stem Cells
Causes Ectopic Niche Formation in the Drosophila Testis"; Phylis Hetie et al.
In a normal testis, the germline stem cells are surrounded by somatic stem cells
at a ratio of about one germline stem cell for every two somatic stem cells
Recent work suggests that somatic stem cells
may have a much greater differentiation potential in different types of cells than previously thought (in experimental conditions, bone marrow stem cells are capable of differentiating into neurons, skeleton-muscular cells and cardiac muscle cells); therefore, the question arises whether research on embryonic stem cells is useful.
Studies that link fetal exposure to toxicants or other substances affecting somatic stem cells
that later populate organs such as the mammary gland, the prostate gland, and the lung, and that have cancer as the end point, are sought by the NCI.
The companies say their first project will focus on the development of sterile disposable processing sets of cryopreservation protocols to provide cryopreserved therapeutic doses of cell populations derived from Kourion's proprietary unrestricted somatic stem cells
(USSC) isolated from placental/umbilical cord blood (PBC).