Indeed, despite the accumulation of evidence for the presence of synaptic dysregulation in SZ, the success of therapeutic strategies designed to modulate glutamatergic synaptic transmission
has been limited.
New experimental evidence indicates that small changes in the structure of astrocytic processes at excitatory synapses can change profoundly the strength of synaptic transmission
in the brain.
Neugebauer, "Non-pain-related CRF1 activation in the amygdala facilitates synaptic transmission
and pain responses, "Molecular Pain, vol.
Yan, "A[beta] impairs nicotinic regulation of inhibitory synaptic transmission
and interneuron excitability in prefrontal cortex," Molecular Neurodegeneration, vol.
Our previous study showed that GluR5-containing kainate receptors (non-NMDA glutamate receptor) regulate the inhibitory synaptic transmission
through endogenous glutamate; therefore, we tested how neonatal propofol and etomidate exposure affect endogenous glutamatergic tonic regulation to inhibitory synaptic transmission
in P90 approximately rats.[sup] To determine whether NMDA receptors are involved in the tonic glutamatergic input on GABAergic neurotransmission, we tested the effect of AP5, a selective NMDA receptor antagonist, on sIPSCs.
(26,27) Accordingly, the inhibition of mEPSCs suggested that the ketamine-induced inhibition of excitatory synaptic transmission
was resulted from the blockade of the postsynaptic glutamatergic receptors.
, the essential process in brain physiological functions, is critical in the signal integration activities of the central nervous system (CNS).
Alterations in expression of several proteins (i.e., tyrosine hydroxylase, PSD-95 postsynaptic density protein), alterations in dendritic spine morphology, and decreased NMDAR-mediated synaptic transmission
all accompanied the loss of LTD.
Here, the cellular location of Pp[Ca.sub.V][beta] was determined using standard immunolocalization techniques with both isolated cnidocytes and cnidocytes in situ to determine if it is involved in the exocytotic events that underlie cnidocyte discharge, synaptic transmission
to elements of the animal's nervous system, or both.
Differential modulation of synaptic transmission
by calcium chelators in young and aged hippocampal CA1 neurons: evidence for altered calcium homeostasis in aging.
The released GABA strongly inhibits neighbouring neurons to cause impairment in synaptic transmission
, plasticity and memory, the findings showed.
AD arises due to the failure of synaptic transmission
, which results in eventual death of the neurons present in the brain.