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"T-cell receptors isolated from minor H antigen-specific T cells represent an untapped resource for developing targeted T-cell immunotherapy to manage leukemia relapse," Bleakley maintains, adding that the construct used in this study could serve as a prototype for others targeting similar antigens.
Type II enteropathy-associated T-cell lymphoma: a distinct aggressive lymphoma with frequent [gamma][delta] T-cell receptor expression.
Sim et al., "Clinicopathologic features and T-cell receptor gene rearrangement findings of mycosis fungoides palmaris et plantaris," Journal of the American Academy of Dermatology, vol.
Even more exciting is that this T-cell receptor treatment targets only cancer cells, leaving healthy cells alone.
Flow cytometry (FCM) showed CD3 [sup]+ , CD8 [sup]+ , CD57 [sup][+ or -] , CD56[sup]− , and restricted expression of T-cell receptor (TCR)-aa3.
The kit determines whether T-cell receptor excision circles (TRECs) DNA is low or missing.
The study presented at the International Liver Congress 2014 detected and expanded MHC-multimer-positive CD8+ T-cells specific for targeted GPC3 epitopes and grew T-cell clones, from which the most specific and active T-cell receptor was isolated.
Histopathologic appearance was consistent with a diagnosis of ATLL, and T-cell receptor rearrangement studies revealed a monoclonal band.
Researchers at the School of Medicine are part of a team that has developed an artificially enhanced molecule, called a T-cell receptor, derived from a white blood cell, that targets and kills melanoma cells.
Th1/Th2-based immunotherapies, e.g., T-cell receptor (TCR) peptides and interleukin-4 (IL-4) injections, have produced mixed results to date.
The research team used a T-cell receptor from a cancer patient cloned by other scientists that seeks out the antigen expressed by this type of melanoma.
The current screening method for SCID is by the T-cell receptor excision circles assay (1), which detects the presence or absence of an excised segment of DNA; however, molecular techniques are not routinely adopted in many newborn-screening laboratories, where an immunoassay would be preferred.

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