The mRNA expression of the CYP19A1 gene, specific for granulosa cells, only was detected in cumulus and follicular cell pellet; CYP17A1 gene, specific for theca cells
, was detected only in follicular cell pellet.
derived from PCOS ovaries and propagated in long-term culture demonstrate increased CYP11A expression compared to normal theca cells
Once the follicle is ruptured to release the mature oocyte, the remaining granulosa and theca cells
differentiate into the corpus luteum.
Thus, inhibiting oocytes and granulosa cells apoptosis and maintaining theca cell
growth are the potential strategies to promote the formation of dominant follicle or mature follicle.
In vivo treatment with GDF-9 stimulates primordial and primary follicle progression and theca cell
marker CYP17 in ovaries of immature rats.
In theca cells
, there was no difference in mRNA expression for CYP17A1, HSD3B2 and STAR between dominant follicles treated with saralasin or vehicle during follicular deviation (FERREIRA et al., 2011a).
Increased transcription and increased messenger ribonucleic acid (mRNA) stability contribute to increased GATA6 mRNA abundance in polycystic ovary syndrome theca cells
. J Clin Endocrinol Metab 2005;90:6596-602.
High levels of FSH and LH in the GFF to stimulate follicular development and granulosa cells and theca cells
so as to increase the secretion of estrogen as well as LH and FSH stimulates the maturation of acolytes contained within follicles.
In the early luteal phase granulosa and theca cells
form corpus luteum with high level of angiogenesis.
The creation of an artificial ovary is the first time researchers have successfully created a three-dimensional environment that contains the three main types of ovarian cells: theca cells
, granulose cells and eggs or oocytes.
To create the ovary, the researchers formed honeycombs of theca cells
, one of two key types in the ovary, donated by reproductive-age (25-46) patients at the hospital.
In the ovaries, in addition to dysregulation of cytochrome p450cl7, insulin has shown to up-regulate the enzyme 17,20 lyase in the androgen-producing theca cells
of the ovaries, which contributes to androgen dominance.