2013), did not increase mRNA levels of the steroidogenic enzyme CYP17A1 in cultured theca cells
treated for 30min, 1-, 3-, 6-, 12- or 24-h (Figure 1A-F).
Baillargeon and Nestler (39) postulated the former view as the cultured theca cells
from PCOS women secrete more androgen upon insulin stimulation compared to normal cells.
Tumors of the specialized gonadal stroma in human male patients: androblastoma, Sertoli cell tumor, granulosa theca cell
tumor of the testis, and gonadal stromal tumor.
The increased LH successively promotes theca cell
androgens production, while the relative FSH deficiency interferes with granulosa cell aromatization to estrogens and impairs follicle maturation and ovulation (7).
After incubation, the theca cells
were stored at -20[degrees]C.
Larner, "Decreased myoinositol to chiro-inositol (M/C) ratios and increased M/C epimerase activity in PCOS theca cells
demonstrate increased insulin sensitivity compared to controls," Endocrine Journal, vol.
Augmented androgen production is a stable steroidogenic phenotype of propagated theca cells
from polycystic ovaries.
and theca cell
conditioned medium inhibit the progression of FSH induced meiosis of bovine oocytes surrounded by cumulus cells connected to membrana granulosa.
The creation of an artificial ovary marks the first time researchers have successfully created a three-dimensional environment that contains the three main types of ovarian cells: theca cells
, granulose cells, and the eggs or oocytes.
For this work, the researchers started with theca cells
, which form the outer coating of the follicle that holds the egg and produces a precursor to oestrogen.
During the antral phase, both the granulosa and theca cells
proliferate, but there is little if any change in the size of the oocyte.