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Real time endobronchial ultrasound guided transbronchial needle aspiration is a method that combines endoscopic visualisation, with high frequency ultrasound imaging which is used to obtain cytology and histology samples of the lesion adjacent to the transbronchial tree.
Woolhouse et al., "Endobronchial ultrasound-guided transbronchial needle aspiration for the diagnosis of intrathoracic lymphadenopathy in patients with extrathoracic malignancy: a multicenter study," Journal of Thoracic Oncology, vol.
Kocjan et al., "Combination of endobronchial ultrasound-guided transbronchial needle aspiration with standard bronchoscopic techniques for the diagnosis of stage I and stage II pulmonary sarcoidosis," Respirology, vol.
Conventional vs endobronchial ultrasound-guided transbronchial needle aspiration: a randomized trial.
Utility of endobronchial ultrasound-guided transbronchial needle aspiration in patients with tuberculous intrathoracic lymphadenopathy: A multicentre study.
Test performance of endobronchial ultrasound and transbronchial needle aspiration biopsy for mediastinal staging in patients with lung cancer: systematic review and meta-analysis.
CT fluoroscopy guidance for transbronchial needle aspiration: an experience in 35 patients.
"Given the low sensitivity and negative predictive value of transbronchial needle aspiration [TBNA] biopsy, patients with a negative result should undergo mediastinoscopy," Dominic Gallo, M.D., said during a poster session at the annual meeting of the American College of Chest Physicians.
Endobronchial lesions that can be directly visualized through a bronchoscope are commonly sampled using bronchial washings and brushings, and transbronchial needle aspiration. Conventional transbronchial needle aspiration is an established method for cytologic evaluation of thoracic mass lesions, but it is limited by the fact that it is a blind procedure.
Endobronchial ultrasound with transbronchial needle aspiration (EBUS-TBNA) is a minimally invasive and safe technique which is universally accepted for the mediastinum and/or hilum lymph node biopsy.

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