Further, duplications and triplications
of the SNCA locus cause familial parkinsonism and correlate with disease severity [19, 20].
Additionally, [-a.sup.3.7] deletion and alpha-globin triplication
anti-3.7 kb type were observed in an Iraqi family with beta-thalassemia (6).
Down Syndrome (DS) results from triplication
of all or part of human chromosome 21 and affects 1 in 700 newborns and is manifested with variable phenotypes such as congenital heart defects, craniofacial abnormalities and cognitive impairment (132).
Furthermore, conventional cytogenetic analysis revealed a complex karyotype including a segmental tandem triplication
of chromosomal bands 11q22-q25.
To determine the capability of HRM to detect mosaicism, the assay was also performed using bisulfite-treated DNA from 2 AS patient samples known to be mosaic and a PWS patient sample with a putative triplication
of the SNRPN promoter region on the maternally derived chromosome 15 (as determined by semi-quantitative MSP, fluorescence in situ hybridization, and micro-satellite analysis).
In the case of route 1, which was to link Kirkby with the city centre, it would have been wasteful triplication
because as well as frequent bus services, Kirkby is well served by trains.
It says the existence of three central bodies [ETH] the BHB, Jockey Club and Levy Board [ETH] has led to racingOs structure being too complex, causing disagreement, triplication
of effort in many instances, excessive bureaucracy and inflated staff numbers.
"It's the money and the duplication - no, the triplication
," Dahle said.
Then England meet South Africa next week, a triplication
of this fixture in the same period of time.
Find three products from the same supplier that interest you and you will get three pages of information plus a pile of what I must now, due to its triplication
, call junk.
This suggests that a certain amount of [alpha]-synuclein may be necessary to exert these pathological effects, as indicated by the genetic PD forms due to gene duplication and triplication