Several studies have found that even if all undifferentiated cells
are purged [26, 34], iPSC derivatives remain tumorigenic, as substantial tumors were present instead of teratomas.
Up to the second passage, the cell population was heterogeneous (Figure 1(a), top panels), probably because it was composed by differentiated and undifferentiated cells
; cells displayed different morphologies, from rounded to spindle-like and different sizes.
(2003) The undifferentiated cell
zone is a stem cell zone in adult rat adrenal cortex.
For two animals in each test (four animals in all), the percentage of [[H.sup.3]]Tdr-labeled nuclei from the total number of nuclei of undifferentiated cells
(UCs) was calculated from EM autoradiographs.
DISCUSSION: Malignant small round cell tumours are characterized by small, round, relatively undifferentiated cells
. They generally include Ewing's sarcoma, peripheral neuroectodermal tumour, rhabdomyosarcoma, synovial sarcoma, non-Hodgkin's lymphoma, retinoblastoma, neuroblastoma, hepatoblastoma and nephroblastoma.
"The application of this antibody should be of interest for researchers studying the biology and induction of pluripotent stem cells, as well as providing a reagent to detect and aid in the removal of residual undifferentiated cells
," said Dr.
After differentiation, hepatocytes show more sensibility to the toxic damages than undifferentiated cells
due to the existence of toxic substances metabolizing enzymes," he added.
The researchers could neutralise the activity of survivin in the undifferentiated cells
as well as in the tumours, and thus managed to initiate programmed cell death (apoptosis) in those cells.
Furthermore, rather than producing additive effects on DNA synthesis, nicotine actually protects undifferentiated cells
from the adverse effects of CPF (Qiao et al.
After removing 50 to 100 undifferentiated cells
and expanding them in culture over several months until their numbers exceeded 25 million, the cells were induced to become neurons.
These primitive, undifferentiated cells
are capable of being coaxed into developing along one of several cell lines, including brain cells.