The increase in sub-haploid VYS cells in the diabetic group probably corresponded to apoptotic cells with fragmented DNA or condensed chromatin (33), as evidenced by the significant proportion of activated caspase-3-expressing cells in that group.
VYS cells from diabetic animals showed low proliferation at gd 15.
In this report, we observed a negative effect of severe hyperglycemia on pregnancy and VYS viability, as evidenced by reduced fetal weights, and increased numbers of unviable and apoptotic VYS cells.
Rat visceral yolk sac (VYS) and placenta mitochondrial features during the placentation period.
Representative flow cytometry plots of VYS cells from the control and diabetic groups.
A, Flow cytometry plots of visceral yolk sac (VYS) cells from control and diabetic groups stained with rhodamine 123.