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Efficacy was significantly higher in the TJ-15 group based on the total score for the accessory symptoms of hypertensions which was the primary efficacy endpoint (Wilcoxon's rank sum test, p = 0.013).
In conclusion, TJ-15 was superior to placebo with respect to efficacy, safety, and utility for the treatment of accessory symptoms of hypertension.
Keywords: Orengedokuto; Kampo medicine (Japanese herbal medicine); Double-blind; Placebo-controlled study; Accessory symptoms of hypertension