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The severity of 5 accessory symptoms of hypertension (irritability, anxiety, sleep disorder, hot flushes, and facial suffusion) and 4 general symptoms (headache/heavy-headedness, shoulder stiffness, dizziness, and malaise) was classified into the following 4 grades at 2-week intervals during both the observation and treatment periods:</p> <pre> -
Changes of the accessory symptoms of hypertension were assessed by the investigator in Week 4 (interim evaluation) and week 8 (final evaluation) based on comprehensive evaluation of the 5 accessory symptoms.
The utility rating was classified into 5 grades in Week 4 (interim evaluation) and Week 8 (final evaluation) by making a comprehensive evaluation of the changes of the accessory symptoms of hypertension, the changes of general symptoms, and the overall safety rating: