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Related to acetylcholinesterase: Acetylcholinesterase inhibitors
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One key learning objective of this exercise is that the neurotransmitter, acetylcholine, is released by the neuron and must be broken down by acetylcholinesterase in the synapse in order to allow the muscle to relax.
After the discovery that the alkaloid huperzine A is a potent acetylcholinesterase inhibitor and, consequently, very important for the symptomatic treatment of Alzheimer's disease, the interest in the isolation and characterization of alkaloids from Lycopodi-aceae has increased exponentially (Liu et al.
Inhibitory effects (%) of the extracts of lyophilized biomass taken from Lake Ladoga water blooms on cell viability (cytotoxic activity) and on trypsine and acetylcholinesterase activities (-, no data) Assay Stations in Lake Ladoga 87 92 4 6 17 Cytotoxic activity - - 50 50 50 Trypsine inhibition activity 93 68 93 96 99 Acetylcholinesterase inhibition activity - - 27 26 31 Table 2.
The adhesive role of acetylcholinesterase (AChE): detection of AChE binding proteins in developing rat spinal cord.
Differential effect of anionic and cationic drugs on the synaptosome associated acetylcholinesterase activity of dog brain.
The other drugs that inhibit cholinesterase or acetylcholinesterase and are approved for the same indication are Aricept (donepezil) and Exelon (rivastigmine).
Phenserine is a highly selective, reversible acetylcholinesterase inhibitor which may offer an alternative to drugs currently marketed for Alzheimer's Disease.
The effectiveness and safety of the coadministration of memantine HCl extended release and acetylcholinesterase inhibitors (AChEIs), together with donepezil HCl, was based on the results of a randomized and double-blind, placebo-controlled study of 677 outpatients on a stable dose of AChEIs.
of the Minneapolis VA Health Care System, and colleagues examined the effectiveness and safety of vitamin E, memantine, and the combination for treatment of functional decline in patients with mild to moderate AD who were taking an acetylcholinesterase inhibitor (a chemical that increases the level and duration of action of the neurotransmitter acetylcholine).
Because new compounds exhibiting specific anti-acetylcholinesterase activity are being sought as possible drug candidates for the treatment of Alzheimer's and related neurodegenerative diseases, compounds 1-18 were examined for their inhibitory activities against acetylcholinesterase and butyrylcholinesterase.
The results indicate that essential oils obtained from Melissa officinalis leaf and Citrus aurantifolia leaf showed high acetylcholinesterase and butyrylcholinesterase coinhibitory activities.

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