rebound

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This hypothesis is supported by evidence of an increased prevalence in acid-related conditions, more liberal prescribing habits--including empirical PPI therapy for unspecific dyspepsia--and PPI "dependency" as a result of acid rebound that requires more and more suppression, he said.
There is evidence of an increased prevalence in acid-related conditions, more liberal prescribing habits--including empirical PPI therapy for unspecific dyspepsia--and PPI "dependency" as a result of acid rebound that requires more and more suppression, Dr.
"The observation that more than 40% of healthy volunteers, who have never been bothered by heartburn, acid regurgitation or dyspepsia, develop such symptoms in the weeks after cessation of PPIs is remarkable and has potentially important clinical and economic implications," said Christina Reimer, MD, of Copenhagen University and lead author of the study/This study indicates unrecognized aspects of PPI withdrawal and is a very strong indication of a clinically significant acid rebound phenomenon that needs to be investigated in proper patient populations."