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The observation that more than 40% of healthy volunteers, who have never been bothered by heartburn, acid regurgitation or dyspepsia, develop such symptoms in the weeks after cessation of PPIs is remarkable and has potentially important clinical and economic implications," said Christina Reimer, MD, of Copenhagen University and lead author of the study/This study indicates unrecognized aspects of PPI withdrawal and is a very strong indication of a clinically significant acid rebound phenomenon that needs to be investigated in proper patient populations.
In fact, there is little evidence that acid rebound is a problem in healthy people.
And prolonged use can actually cause an increase in the production of stomach acid if you suddenly stop taking the antacids--this is called acid rebound.