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In the case of LD SCCB, chemotherapy was administered (neo) adjuvantly to surgery, as well as in combination with radiation.
Of the group of four patients with STR, two were monitored clinically and treated after evidence of disease progression, and the remaining two were treated adjuvantly with radiation for the following reasons.
The most recent results assessing the efficacy of adjuvant chemotherapy have been reported by the National Research Council in Italy where patients with pT2 or higher-staged disease were randomized to receive 4 cycles of GC given adjuvantly or at time of relapse (salvage).