remodeling

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Airway remodeling occurs in patients in whom asthma is not adequately controlled over a long period of time.
Protein linked to allergic response causes airway changes in asthmatics
Despite its established pro-inflammatory actions on COPD, the action of PAF on airway remodeling has been still unclear.
Effect of platelet-activating factor on cell proliferation & NF-[kappa]B activation in airway smooth muscle cells in rats
Nor was there a difference in postbronchodilator forced expiratory volume, demonstrating that regular ICS did not significantly affect airway remodeling.
Are daily inhaled steroids appropriate for mild persistent asthma?
A comparison of terminal airway remodeling in chronic daily versus episodic ozone exposure.
The role of inflammatory mediators in the synergistic toxicity of ozone and 1-nitronaphthalene in rat airways
START also provided evidence that budesonide may modify the long-term process of airway remodeling that is believed to be associated with asthma exacerbations.
Early inhaled steroids beneficial in mild asthma: budesonide cut risk of severe exacerbations by 44% in large 'real-world' clinical trial. (Cost-Effective Intervention)
SLPI also impacts mast cell chymase and tryptase, and thrombin, each of which may be involved in airway remodeling in asthma.
Arriva Pharmaceuticals Granted Fusion Protein Patent
Additionally, as we expand our body of knowledge about IL-9's role in mast cell regulation, airway remodeling, and other functions involved in the onset of asthma symptoms, we believe these preclinical data provide further support for IL-9 inhibition as a potential therapeutic approach to treating patients with moderate to severe asthma.
MedImmune Highlights Advances in Inflammatory Disease Pipeline With Series of Data Presentations
Chronic, repeated inflammatory challenge of the airways may result in airway remodeling that leads to irreversible lung disease.
The U.S. Environmental Protection Agency particulate matter health effects research centers program: a midcourse report of status, progress, and plans. (Research Review)
TOPIGEN's other COPD program, PD3, is an aerosolized phosphodiesterase inhibitor being developed to target multiple gene-expression pathways linked to the progressive airway remodeling associated with COPD.
TOPIGEN Outlines Strategy for Respiratory Disease Product Pipeline
We conclude that PM penetrates into and is retained in the walls of small airways, and that, even in nonsmokers, long-term exposure to high levels of ambient particulate pollutants is associated with small airway remodeling.
Chronic exposure to high levels of particulate air pollution and small airway remodeling. (Research)
Delivered via aerosol, PD-3 is designed to inhibit several gene expression pathways linked to the progressive airway remodeling associated with COPD.
TOPIGEN Announces Presentations at Inaugural Meeting of the Oligonucleotide Therapeutics Society
Delivered via aerosol, the product (PD-3) is designed to inhibit gene expression pathways linked to the progressive airway remodeling associated with the disease.
TOPIGEN Introduces FANA(TM) Technology, New 3rd Generation Chemistry for Oligonucleotide-Based Therapeutics

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