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Alterations in ADAM33 activity may influence the function of these cells, thereby resulting in airway remodeling (12).
32,33) Although the mechanisms are discussed below as distinct theories, there is considerable overlap between them, and it is likely that emphysema and airway remodeling are a consequence of the interplay of the inflammatory and immunologic systems, resulting in genetic alterations and abnormal maintenance and repair of the lung.
An imbalance between MMP-9 and TIMP-1 is considered a principal explanation of emphysema in airway remodeling and that has been observed to be associated with a variety of pulmonary inflammatory diseases (Gueders et al.
Mistletoe Extract Helixor Treatment Attenuates Allergic Airway Remodeling in a Mouse Model of Asthma.
45 According to the viewpoints of Churg cigarette smoke may drive small airway remodeling by induction of growth factors in the airway wall12 which explains why smoking can promote PAFL.
They attributed this to an individual pattern of the response to frequent exacerbations or the process of airway remodeling.
Both conditions are chronic inflammatory diseases of the lower airway that can lead to irreversible 11 image called airway remodeling.
His worked focused on neurogenic inflammation and airway remodeling.
Aside from airway remodeling and the associated risk of developing bronchogenic carcinoma, chronic bronchitis patients experience airway inflammation and retention of mucus both of which cause partial and complete airway obstructions.
While aggressive therapy with oral and high-dose inhaled corticosteroids often improve symptoms as long as the child is using them, they are not disease modifying and don't prevent severe airway remodeling.
Those patients are at risk for airway remodeling, with structural changes that can include angiogenesis, thickening of the basement membrane, alterations in cartilage, and increase in smooth muscle.
Background & objectives: Despite the established pro-inflammatory actions of platelet activating factor (PAF) observed on chronic obstructive pulmonary disease (COPD), its action on airway remodeling has been still unclear.

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