administered sublingually are taken up by dendritic cells in the oral mucosa and presented to T cells in the draining lymph nodes, likely resulting in activation of regulatory T cells and downregulation of mucosal mast cells.
The one remaining standardized SLIT product under FDA review is Ragwitek, a short Ragweed pollen allergen extract
, developed by Merck in partnership with ALK of Denmark.
Additionally, the quality of natural HDM allergen extracts
and vaccines based on these extracts is often poor.
The tablet is based upon a formulation of allergen extracts
from the two major species of HDM: Dermatophagoides pterornyssinus and D.farinae.
To simulate real-life exposure, we developed a system whereby we could challenge the subject with aerosolized whole pollen grains rather than using allergen extracts
as in earlier human experimental exposure studies.
FDA approves first sublingual allergen extract
for the treatment of certain grass pollen allergies [online press release].
Microarray assays require <1 nL of allergen extract
per test, which allows the use of the more expensive allergen extracts
used for SPT in microarray production.
The recruitment of participants for the atopic group of this study was based on clinical history of allergic rhinitis and positive SPT to at least Dpt allergen extract
. A previous study in patients of the Triangulo Mineiro region, Brazil , showed high positivity percentages to HDM extracts, underlining D.