Alpha cells, on the other hand, showed relatively low counts in early postnatal period and slight gain in one week old age group.
The relative ratio of beta and alpha cells was seen to be closer to the adult ratio than in early postnatal days.
Age 25 yrs., Alcoholic, Chrome Alum Haematoxylin Stain (X400) Alpha cells, B--Beta cells
Non-Alcoholic, Azocarmine Stain (X400) Alpha cells, B--Beta cells
The researchers found that some of the insulin-producing cells also made glucagon, a hormone that is normally made by alpha cells
. The finding suggested that the beta cells in the mice had once been alpha cells
Beta cell preparations consisted of 90% insulin+, 3% glucagon+, 1% somatostatin+, and 2% pancreatic polypeptide+ cells; alpha cells
contained 2% insulin+, 94% glucagon+, 1% somatostatin+, and 2% pancreatic polypeptide+ cells, as previously described [10, 12].
The current method f producing beta cells leads to cells that resemble alpha cells
a little too much.
Thirdly, it has been well documented that GLP-1 analogs could suppress inappropriate secretion of glucagon from alpha cells
. However, despite certain controversy, there are some reports showing that incretin therapy may induce hyperplasia of pancreatic alpha cells
in human and rodent models [19-21].
"Our study shows that neighboring cells called alpha cells
can behave like adversaries for beta cells.
While the alpha cells
of the pancreas that produce glucagon are not destroyed in people with type 1 diabetes, the cells no longer release glucagon in response to low blood sugar.
They have found that when the gene called Pax4 is forced on in pancreatic alpha cells
, the cells change their identity to become beta cells.
Produced by the alpha cells
in the pancreas, glucagon acts on the liver to help raise blood glucose when it becomes low.