As a result of the promising work published in Cytotherapy, the University of Minnesota and BioE recently entered into a joint research collaboration to further evaluate the use of the MLPC for creating airway epithelial cells, such as type II alveolar cells
, that could aid in combating diseases such as emphysema and cystic fibrosis, as well as pulmonary injury due to therapy-related causes.
In the case of the MLPC, researchers have demonstrated its endodermal potential by turning it not only into liver and pancreas precursors, but now, alveolar cells
carcinoma of the lung (pulmonary adenomatosis, jagziekte?
To validate the relevance between TAZ expression and treatment response in NSIP, we also compared TAZ expression in fibroblasts, bronchiolar cells, and alveolar cells
between the good response and nonresponse groups.
In relation to the presence of pluripotent cells, it was verified the co-location of these Oct-4+ cells with those who were on proliferative phase, especially in the epithelial bronchi and bronchioles, and also on alveolar cells
of the Groups I and II (Figure 3E).
10,11 There are two types of alveolar cells
, type I and type II pneumocytes.
Different clinical findings of Hermansky Pudlak syndrome occur as a result of dysfunction of lysosome-related organels including melanosome, platelet granules and lamellar parts of type 2 alveolar cells
Figure 2 summarizes the signaling effects mediated by the various alveolar cells
in response to xenobiotic exposure.
Differentiation of MSCs into epithelial type II cells may partially restore the stem cell pool, leading to increased genesis of alveolar cells
for the resolution of disrupted alveolar surfaces, thereby augmenting the repair process.
In mink kits, AD causes an acute cytopathic infection of alveolar cells
, which leads to respiratory distress and death (8).