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Related to angiogenesis inhibitor: tumor angiogenesis
See: deterrent
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The clinical efficacy of angiogenesis inhibitors has recently been met with numerous phase III failures that showed modest survival benefits because tumors elicit evasive resistance [151].
Hamby et al., "Crystal structure of an angiogenesis inhibitor bound to the FGF receptor tyrosine kinase domain," EMBO Journal, vol.
Stack et al., "Human prostate carcinoma cells express enzymatic activity that converts human plasminogen to the angiogenesis inhibitor, angiostatin," Cancer Research, vol.
Study sheds light on angiogenesis inhibitors, points to limitations, solutions [press release].
Drugs called angiogenesis inhibitors prevent the growth of blood vessels that supply tumours with oxygen and nutrients.
Further research is needed to determine which markers will help us to predict the activity of cetuximab and panitumumab in addition to KRAS status and also to find predictive markers for angiogenesis inhibitors.
The expression of a 567-bp transcript that was 90% identical to human brain-specific angiogenesis inhibitor 3 (BAI3) was determined to be unchanged based on differential display (Table 1).
A novel endogenous angiogenesis inhibitor, Vasohibin-1 (VASH1), was identified in a microarray analysis performed to explore genes upregulated by VEGF-A in endothelial cells [96].
Methyl 2-cyano-3,11-dioxo-18-olean-1, 12-dien-30-oate(CDODA-Me), a derivative of glycyrrhetinic acid, functions as a potent angiogenesis inhibitor. J.
14 ( ANI ): Researchers have found that adding the chemotherapy drug carboplatin or the angiogenesis inhibitor Avastin to standard chemotherapy drugs resulted in a sharp decline in women suffering from "triple-negative" breast cancer.
Other authors reported enhancing effect of theanine, a component of green tea leaves, on the antitumor activity of adriamycin [71], inhibition of liver metastasis of human pancreatic carcinoma by angiogenesis inhibitor TNP-470 (analog of fumagillin derived from Aspergillus fumigatus) in combination with cisplatin in nude mice [72], and augmented antitumor effects of combination therapy cisplatin/TNP470/IL-12 in melanoma (B6D2F1 mice) and colon carcinoma (Balb/c mice) [73].
Angiogenesis inhibitor therapies: focus on kidney toxicity and hypertension.