With the multiple small strokes and transient neurological symptoms happening within a short period and coupled with some cognitive decline, the neurologists begin to explore the possibility of cerebral amyloid angiopathy
MRI-visible perivascular spaces in cerebral amyloid angiopathy
and hypertensive arteriopathy.
The constant increase rates and an aging population with a higher prevalence of hypertension and cerebral amyloid angiopathy
, with a widespread use of AT and OACT, have an impact on the clinical picture and mortality [30, 31].
Factors that demonstrate higher risk of hemorrhagic complications include lobar ICH and imaging suggestive of cerebral amyloid angiopathy
(multiple microbleeds on gradient-echo magnetic resonance imaging) .
This cerebral hypoperfusion condition in patients with AD could be the result of small vessel damage driven by amyloid angiopathy
, a landmark of AD brain findings among other alterations .
Beirao et al., "The use of intravitreal ranibizumab to treat neovascular glaucoma because of retinal amyloid angiopathy
in familial amyloidosis transthyretin v30m related," Retinal Cases & Brief Reports, vol.
The [epsilon]2 and [epsilon]4 alleles of APOE are implicated with the pathogenesis of cerebral amyloid angiopathy
Further, arguing against an atypical presentation of AD, the extensive and severe amyloid pathologies typical of advanced AD neuropathology were not seen (Thal phase was 3, neuritic plaque pathology was sparse, and no cerebral amyloid angiopathy
Clark et al., "Surgical outcomes for moyamoya angiopathy
at barrow neurological institute with comparison of adult indirect encephaloduroarteriosynangiosis bypass, adult direct superficial temporal artery-to-middle cerebral artery bypass, and pediatric bypass: 154 revascularization surgeries in 140 affected hemispheres," Neurosurgery, vol.
The authors showed that the absence of ABCB1 results in a significant disturbance of A[beta] removal in a transgenic murine model of AD (APP/P[S1.sup.+/-]-ABCB1), leading to an increased intraparenchymal cerebral amyloid angiopathy
. We need to consider that if on the one hand, the BBB and ABCB1 are both neuroprotective; on the other hand, they are substantial obstacles to the delivery of drugs to the CNS.
Cerebral amyloid angiopathy
(CAA) has been recognized as one of the morphologic hallmarks of Alzheimer disease (AD), resulting from deposition of amyloid in the media and adventitia of small arteries and capillaries of the leptomeninges and cerebral cortex, which is associated with cerebral microbleeds and white matter hyperintensities .
The same authors have also shown that in transgenic AD model mice the antiplatelet agent clopidogrel (an ADP receptor [P2Y1, 2] blocker) reduced the amount of clusterin in the circulation and the incidence of cerebral amyloid angiopathy