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Related to antigen-binding site: variable region, Surface immunoglobulin
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Phage display, using combinatorial peptide libraries, is a relatively straightforward method for identifying suitable peptides for binding to the antigen-binding site of mAbs (27).
When two polypeptide chains, VHA-VLB and VHB-VLA, linked by the short linkers are expressed in the same cells, dual-functional antigen-binding sites are formed by crossover pairing of the variable light-chains and heavy-chains.
Both of these points maybe linked to the observation that as a result of the half-antibody exchange reaction (Fab-arm exchange), most IgG4-type antibodies are bispecific antibodies with two different antigen-binding sites that make the molecules functionally monovalent for a given antigen (25).

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