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An antimicrobial stewardship program reduces antimicrobial therapy duration and hospital stay in surgical wards.
Knowledge of the MIC allows for more tailored antimicrobial therapy through improved choice of agent guided by an understanding of the pathogen and its MIC distribution, and (through application to simulated pharmacological data) the likely probability of Pk-Pd target attainment.
The shorter time to diagnosis needs to be correlated with a real-time report to the clinical team to be translated into an effective intervention that improves antimicrobial therapy. Beganovic et al.
The initial empirical antimicrobial therapy was considered "appropriate" if the initial antibiotics included at least one antibiotic that was active in vitro antimicrobial susceptibility testing results and when at least the minimum recommended dose was administered via the intravenous route [9].
In addition, before the antimicrobial susceptibility results arrived, the postintervention patients were more likely to be on active antimicrobial therapy (77%) than the preintervention patients (47%; p = 0.005).
However, where PCT appears to show some promise in the management of sepsis is in guiding earlier discontinuation of antimicrobial therapy.
I mpact of inappropriate empiric antimicrobial therapy on mortality of septic patients with bacteremia: a retrospective study.
Empirical antimicrobial therapy for suspected LOS should, ideally, cover both Gram-positive and Gram-negative organisms.[3,6] In developed countries, 95% of organisms causing LOS are sensitive to a combination of gentamicin with either amoxicillin or flucloxacillin, [6] or amoxicillin plus cefotaxime.
According to the company, the vaccination schedule for this new expanded indication consists of three doses of BioThrax (Anthrax Vaccine Adsorbed) administered at zero, two and four weeks post-exposure combined with antimicrobial therapy.
Peters pointed out that the studies of antimicrobial therapy for combined diabetic skin and soft tissue infection and osteomyelitis featured 6-28 days of treatment.
Concerns over the volume and frequency of antibiotic injections, combined with the likely duration of treatment, led to the use of a vascular access port to facilitate intravenous antimicrobial therapy. The port was placed and maintained for 5 months without complication, and the infection was resolved.
massiliense native tricuspid valve endocarditis successfully treated with antimicrobial therapy and surgical debridement.

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