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Related to aplastic crisis: aplastic anemia, sequestration crisis
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Acute splenic sequestration together with aplastic crisis caused by human parvovirus B19 in patients with sickle cell disease.
The HPV B19 induced aplastic crisis can unmask several hereditary hematological disorders that have been normally compensated.
Hematologic diseases such as transient PRC aplastic crisis, hydrops fetalis and single or multiple transient parvovirus-related cytopenias (neutropenia, autoimmune thrombocytopenic purpura, pancytopenia) are also seen in immunocompetent patients (4), (5), (7-10), (39).
Nucleotide sequence and genome organization of human parvovirus B19 isolated from the serum of a child during aplastic crisis.
The virus is strongly associated with erythema infectiosum (fifth disease), the transient aplastic crisis observed in patients with hemolytic anemia, arthropathy, and fetal wastage.
A child with aplastic crisis may appear pale and be tired and less active than usual.
One such agent, human parvovirus B19, was "a virus looking for a disease' until 1981--when it was first associated with aplastic crisis, a shutdown of the bone marrow's production of blood cells, says Larry Anderson of the Centers for Disease Control (CDC) in Atlanta.