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The answer is provided by Figure 3 (and partially by the top-ten Table 1) because here, the impact of individual chemicals on aromatase is only conditioned by internal dose and inhibition potency.
Ovary and testis showed similar retention times but the retention times of type II and III differed, which implies that type I aromatase is the major transcript expressed in ovary and testis.
The enzyme aromatase is composed of the product of the CYP19 gene (Bulun et al.
This aromatase is responsible for the biosynthesis of estrogens from androgens such as AED and testosterone (Thompson and Sitteri 1974).
Aromatase is highly expressed in breast cancer tissue, and suppression of in situ estrogen formation by aromatase inhibitors is considered a viable means of preventing and treating breast cancer in postmenopausal women.
Aromatase is responsible for the physiologic balance of androgens and estrogens.