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In conclusion, the dramatic increase observed in aromatase gene expression and in those of other steroidogenic enzyme genes in 2-week pig testes coincide with the temporal production of large amounts of 19-nortestosterone in the 2-4 week testis, which suggests that aromatase is responsible for 19-nortestosterone biosynthesis.
At ~10% inhibition, LH peaks disappear after approximately five cycles, and a major bifurcation in cycle patterns occurs: cycles are further shortened, baseline levels are much increased (doubled for E2 and P4, for example, even though E2 synthesis by aromatase is decreased), and peak levels mostly decreased; E2 distance to normal increases up to a maximum (Figure 2).
This aromatase is expressed in the human prostate, suggesting a local role for estrogen.
Thus, a decrease in aromatase is expected to lead in part to build up of male hormones, which, in turn, further decrease RORA expression, as demonstrated in this study using a neuronal cell model.
The enzyme aromatase is composed of the product of the CYP19 gene (Bulun et al.
This aromatase is responsible for the biosynthesis of estrogens from androgens such as AED and testosterone (Thompson and Sitteri 1974).
Aromatase is highly expressed in breast cancer tissue, and suppression of in situ estrogen formation by aromatase inhibitors is considered a viable means of preventing and treating breast cancer in postmenopausal women.