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The present study, performed in primarilynormotensive rats, had two objectives: 1) to test the effects of sequential exposure, first to a LNa diet for 7 days and then to a HNa diet for 21 days, in rats with and without partial arterial baroreceptor impairment (to simulate the prehypertensive SS baroreceptor systemic phenotype) on SSi and on MAP after 21 days on a HNa diet, and 2) to study the roles of plasma NO bioavailability (pNOB), renal medullary superoxide anion production, and renal mRNA expression of NAD(P)H oxidase and superoxide dismutase (SOD) in such responses.
An improved strategy for evaluating the extent of chronic arterial baroreceptor denervation in conscious rats.
Pre-exercise sympathetic nerve activity in the supine position with elevated legs, expressed through lower ln LF, found in the present study, was probably reflexly suppressed by arterial baroreceptors.