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Regardless of circumstance, HZ/su was always more effective than live attenuated virus (ZVL) according to the two-way sensitivity analysis.
But after introduction of vaccines developed first by Jonas Salk and then an oral vaccine using live attenuated virus developed by Albert Sabin, the crippling disease was conquered.
Sheldon and colleagues (2012) concluded the LAIV4 with the Ann Arbor strain had the similar immunogenic responses to the trivalent live attenuated virus, the original FluMist[R], with broader protection for the second major influenza B virus strain.
Live attenuated virus vaccine is considered to be the most economic method to achieve immunization [17].
Instead of a liquid containing whole killed or attenuated virus, this vaccine uses dry virus-like particles (VLPs) which simply coat the needles in the presence of a simple stabilizing agent, reducing the need for refrigeration - a potential boon for use in developing countries.
However, it is well compatible with the spread of an attenuated virus causing no clinical disease.
Approval of the live, attenuated virus vaccine in the younger age group was based on a multicenter, placebo-controlled study that involved more than 22,000 adults who had a history of varicella but were herpes zoster-negative.
Attenuation of the myxoma virus and use of the living attenuated virus as an immunizing agent for myxomatosis.
ZOSTAVAX (Zoster Vaccine Live) is a live attenuated virus vaccine indicated for prevention of shingles in individuals 50 years of age and older.
Both a nasal-spray-delivered live attenuated virus vaccine and an injectable inactivated virus vaccine will be available.
But an unanticipated difficulty in bulk production of the live attenuated virus vaccine has slowed its progress.