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This suggests that the size and/or characteristics of the inhaled pollutant particles per se are not vital determinants of their capacity to trigger this specific set of acute hemodynamic alterations, which likely occurs via autonomic imbalance.
Published results of the DINAMIT study demonstrate that - in this patient population - ICD therapy can significantly reduce the risk of sudden death in patients with a recent myocardial infarction who are at high risk of arrhythmic death due to extensive myocardial scarring and autonomic imbalance, but that ICD therapy does not result in reduction in total mortality.
Chronic autonomic imbalance is believed to be a risk factor for the progression of heart failure and adverse cardiovascular events.
951) hypothesized that increased risk of triggered arrhythmias 1 day after DE exposure would be mediated by airway sensory nerves bearing transient receptor potential (TRP) channels that, when activated by noxious chemicals, cause a centrally mediated autonomic imbalance and heightened risk of arrhythmia.

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