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Related to autonomic reflex: somatic reflex, autonomic reflex arc
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It is believed that blockade of this receptor would prevent activation of airway sensory nerves and the autonomic reflex arc and would thus prevent the heightened response to aconitine by severing the outgoing signal that connects the autonomic nervous system to the heart.
Among 57 patients for whom autonomic reflex screening was done, 49 (86%) had abnormalities.
The effect of LPR in the pediatric airway might be mediated by one or all of three mechanisms: (1) microaspiration with stimulation of the laryngeal adductor reflux, (2) micro-aspiration with chemical pneumonitis, and (3) stimulation of an esophageal-vagal and/or autonomic reflex that results in or potentiates bronchial constriction.

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