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High concentrations of glucose in culture media have been associated with decreased embryo quality, defined by cleavage rates, degree of fragmentation, and blastocyst development (Coates et al.
Higher maternal body mass index before pregnancy has been associated with a lower risk of having a small-for-gestational-age infant and an increased risk of late fetal death and NTDs (Cnattingius et al.
Such an increase involving deer mouse populations may have been associated with the first recognized outbreak of HPS in the southwestern United States in 1993 (7).