It increased the islet diameter (p<0.001) and beta cell
Gestational diabetes mellitus (GDM) is a common metabolic disease of pregnancy characterized by hyperglycemia resulting in insulin resistance or failure of sufficient insulin production by pancreatic beta cells
(American Diabetes Association, 2014).
Liu et al., "NADPH oxidase inhibition prevents beta cell
dysfunction induced by prolonged elevation of oleate in rodents," Diabetologia, vol.
Life and death of the pancreatic beta cells
. Trends Endocrinol Metab 2000; 11(9):375-8.
Connective tissue growth factor acts within both endothelial cells and beta cells
to promote proliferation of developing beta cells
Although mice with different treatments had varied degrees of insulitis and a variable number of beta cells
per islet (Figure 2), the pancreatic insulin content in mice treated with ATRA (932 [+ or -] 182 ng/mL, n = 3, P = 0.013) and exendin-4 (705 [+ or -] 479 ng/mL, n = 5, P < 0.02) was significantly higher than that of control mice (41 [+ or -] 9 ng/mL, n = 4) (Figure 3).
On the contrary another study suggested that during postnatal development, replication of differentiated beta cells
can lead to addition of new beta cells
, so high rates of beta cell
replication during the neonatal period results in a massive increase in the cell mass (Georgia and Bhushan, 2004).
Fontes, "Glucolipotoxicity of the pancreatic beta cell
," Biochimica et Biophysica Acta, vol.
Critical roles for the TSC-mTOR pathway in beta cell
Tests in mice have shown the mix of three drugs and an antiin-flammatory enzyme renews insulin-producing beta cells
Type 1 diabetes is an autoimmune disorder in which a person's immune system mistakenly destroys the cells that produce insulin (called beta cells
Symptoms of IDDM usually develop over a short period, although beta cell
destruction can begin months, even years, earlier.