The stem cell-dcrived
beta cells are undergoing trials in animal models, including non-human primates, Melton said.
We were very excited when we found obese animals had three times the amount of SIK2 in their
beta cells, meaning they were working harder to compensate for high blood sugar by turning up SIK2," Dr.
You might expect the effect could be quite dramatic if they had good numbers of
beta cells to begin with.
The present study was designed to observe the role of CCT aqueous seed extract on
beta cell regeneration and intra-islet vasculature in alloxan-induced diabetes, hypothesising that it induced both.
Evidence for proteotoxicity in
beta cells in type 2 diabetes: Toxic islet amyloid oligomers from intracellularly in the secretory pathway.
Insulin resistance was calculated by HOMA-IR and
beta cell function by HOMA-b equation.
In rats, perinatal malnutrition impaired neogenesis and the capacity of
beta cell regeneration but preserved
beta cell proliferation which remained the only choice to increase
beta cell mass.
Critical roles for the TSC-mTOR pathway in
beta cell function.
Royal College of Surgeons' Professor Jochen Prehn said: "There is tremendous hope there is capacity to regenerate
beta cells or protect them against immune cell attack.
Tests in mice have shown the mix of three drugs and an antiin-flammatory enzyme renews insulin-producing
beta cells.
Dr Iain Frame, Diabetes UK's research manager, said: "This research demonstrates that there may have been a substantial improvement in
beta cell function.
GLP-1 stimulates pancreatic
beta cells to increase the secretion of insulin, so GLP-1 has the potential to improve
beta cell function itself.
