failure

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Related to bone marrow failure: aplastic anemia

failure

(Bankruptcy), noun commercial failure, default, discontinuance of business, economic downfall, failure to maintain solvency, financial disaster, financial loss, financial ruin, inability to maintain solvency, inability to meet financial obligations, insolvency, insufficiency of funds, lack of funds, suspension of business
Associated concepts: failure to meet one's obligations, insolvency

failure

(Falling short), noun defectio, defectiveness, deficiency, delinquency, dereliction, inability, insufficiency, lack, loss of strength, noncompletion, nonfulfillment, nonperformance, omission, oversight, pretermission, shortcoming, slip, want
Associated concepts: failure of consideration, failure of eviience, failure of heirs, failure of issue, failure of proof, failure of purpose, failure of title, failure of trust, failure to act, faillre to bargain collectively, failure to comply, failure to file a return, failure to give notice, failure to make delivery, failure to perform, failure to prosecute, law office failures, partial failure

failure

(Lack of success), noun aborted attempt, beating, botch, breakdown, collapse, debacle, defeat, disappointment, downfall, drubbing, error, fall, fiasco, fruitless effort, frustration, ineffectualness, labor in vain, loss, miscarriage, misfortune, mistake, ruin, unsuccessful attempt, vain attempt
See also: abortion, bankruptcy, breach, debacle, defeat, delinquency, disaster, dishonor, disqualification, expiration, flaw, foible, frailty, frustration, impossibility, impotence, impuissance, inability, incapacity, inefficacy, infraction, lapse, loss, miscarriage, misconduct, mistrial, neglect, negligence, nonfeasance, nonpayment, offense, omission, oversight, vice
References in periodicals archive ?
Dyskeratosiscongenita, bone marrow failure, and gastric adenocarcinoma: an insight into telomere biology.
Reduced-intensity conditioning may be an option for patients with other problems such as bone marrow failure, immunodeficiencies, or genetic or metabolic problems.
In this case report, we describe the case of a 13-year-old boy who presented with classic symptoms and signs of DC along with bone marrow failure (BMF).
One case was a familial bone marrow failure syndrome which was later diagnosed as Fanconi anemia by chromosomal breakage analysis.
8Most often the Pancytopenia is associated with organomegaly and lymphadenopathy usually suggests the possibility of malignancies or bone marrow failure syndromes but there are a number of other causes which can present in the similar way and are very easily treatable.
The book is divided into thirteen sections: I and II cover inherited and acquired red cell disorders; III inherited white cell and platelet disorders; IV infectious disorders, V hemostatic disorders; VI bone marrow failure syndromes; VII reactive lymphadenopathies; VIII reactive histiocyticlymphoproliferative disorders; XI myeloid neoplasms; XII histiocytoic and dendritic cell neoplasms; and XIII is thymoma and thymic carcinoma.
David Taussig from the Barts Cancer Institute at Queen Mary, University of London, said; the widely accepted explanation has held that AML causes bone marrow failure by depleting the bone marrow of normal hematopoietic stem cells by killing or displacing them.
1-3) DC is a clinically heterogeneous inherited bone marrow failure syndrome (IBMFS), that epitomizes the clinical consequences of very short telomeres and mutations in telomere biology.
Now, a team of researchers led by biologists at the California Institute of Technology has found in mouse models that the molecule microRNA-146a (miR-146a) acts as a critical regulator and protector of blood-forming stem cells (called hematopoietic stem cells, or HSCs) during chronic inflammation, suggesting that a deficiency of miR-146a may be one important cause of blood cancers and bone marrow failure.
An adequate space in bone marrow where red cells are formed is essential, without this space, growth of blood cells is compromised leading to bone marrow failure and severe anaemia.
In addition to creating new capabilities and in vitro assays for drug rescue and predictive toxicology, these advancements open the door to development of new treatments for bone marrow failure, anemia, viral diseases and other conditions that compromise the immune system," said CEO Shawn Singh.
The authors present a classic case of dyskeratosis congenita (DC) and nicely summarize the variability in clinical and diagnostic findings in patients with inherited bone marrow failure syndromes (IBMFSs).

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