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Immune's lead product candidate, bertilimumab, is in phase II clinical development for moderate to severe ulcerative colitis as well as for bullous pemphigoid, an orphan auto-immune dermatological condition.
Neil Korman, MD, PhD, Professor of Dermatology, University Hospitals, Case Medical Center, Cleveland, OH, said, "An autoimmune blistering disease, Bullous Pemphigoid, has no real treatments beyond powerful anti-inflammatory medicines called corticosteroids.
In advanced stages, corneal decompensation can result in bullous keratopathy.
A bullous neutrophilic dermatosis in a patient with severe rheumatoid arthritis and monoclonal IgA gammopathy.
Investigators at Western Michigan University, Kalamazoo, conducted a literature review and an analysis of the Food and Drug Administration's Adverse Event Reporting System database and concluded there is a link between DPP-IV inhibitors and the development of bullous pemphigoid, a potentially fatal cutaneous autoimmune blistering disorder.
1) The differential diagnosis includes bullous pyoderma gangrenosum, erythema multiforme, urticarial vasculitis, rheumatoid neutrophilic dermatosis, and bacterial, mycobacterial, and deep fungal infections.
Bullous pilomatricoma: A rare variant resembling bouncy ball.
The boy's bullous pemphigoid was being treated with dapsone 50 mg per day and corticoid applications.
Key Words: Adnexal tumor, pilomatricoma, bullous appearance, bullous pilomatricoma, anetodermic pilomatricoma
At four months, he was diagnosed with childhood Bullous Pemphigoid.
Melanie Bradley, 34, and 21-month-old Rebecca suffer from the rare disorder bullous ichthyosis that turns skin to tissue.
Out of 4 normal skin and 32 nonpemphigus vesiculobullous disease controls, 1 bullous pemphigoid case showed IgG4 positivity (Figure 1, D), resulting in a specificity of 97.