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In this study, the number of CD8 [sup]+ T cells was significantly higher in the stroma than inside the cancer nest. An additional possibility may be that tumor-infiltrating CD8 [sup]+ T cells contain high levels of T-regs in addition to cytotoxic T cells.
The nuclear staining suggested the role of WT1 in cancer nests proliferation suggesting its oncogenic role in oral squamous cell carcinoma.
Caption: FIGURE 2: The cancer nests of the epithelial cells with a clear cytoplasm and a distinct cell membrane, separated by many capillary vessels (a) and perinephric fat invasion in the renal tumor (b).