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Related to cartilage matrix: perichondrium, endochondral ossification, bone matrix
See: pattern
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2001) have demonstrated that the presence of inflammatory cytokines such as IL-1[beta] and TNF-1[alpha] reduced cartilage matrix synthesis and caused proteoglycan loss.
After 24 hours of incubation, media were collected and stored at -20[degrees]C for analysis of the release of cartilage matrix biomolecules such as hyaluronan (HA) and sulfated-glycosaminoglycans (s-GAGs) and designated as the day zero samples.
Osteoarthritis in the human knee: a dynamic process of cartilage matrix degradation, synthesis and reorganization.
Acute and sustained increase in the release of matrix molecular fragments, proteases, and cytokines from joint cartriage and other joint tissues within hours and days of the injury results in a rapid onset of damage to the type II collagen network, aggrecata, and other critical matrix components of the joint cartilage, leading to a weakened molecular network of the cartilage matrix (J.
Glucosamine is an amino monosaccharide nutrient and precursor of the disaccharide unit of glycosaminoglycan, which is the building block of the proteoglycan component of the cartilage matrix.
5-kDa, as products of cartilage matrix degradation, may be a third matrix fragment system of relevance to OA.
Chapters are in sections on synovial joint morphology, histopathology, and immunohistochemistry; cartilage matrix and bone biology; and cell trafficking, migration, and invasion.
Cartilage preservation: the nutritional content of glucosamine and chondroitin in SaltO3 helps to preserve cartilage matrix.
The rationale for the study was based on the fact that while statins are increasingly recognized for their broad anti-inflammatory effects, they have also been shown to increase the production of nitric oxide, which could have a deleterious effect on the cartilage matrix, the investigators said.
In OA, interleukin-1 (IL1) appears to stimulate the synovial cells and chondrocytes to overproduce enzymes responsible for dissolving the cartilage matrix.
One particular area of interest is chondrocyte metabolism -- the process by which chondrocytes are able to replenish the proteins in the cartilage matrix.