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Related to ceftazidime: ceftriaxone, Cefepime, cefotaxime, ciprofloxacin
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Most ESBL are mutant of classical TEM-1, TEM-2 and SHV-3 [beta]-lactamase types and, unlike these parents enzymes, ESBL hydrolyses oxyimino-aminothiazolyl cephalosporins such as cefuroxime, cefotaxime, ceftriaxone, ceftizoxime, ceftazidime cefpirome and cefeprine as well as penicillins and other cephalosporins except cephamycins (2).
It differs from CTX-M-3 by one amino acid substitution (Asp240 to Gly), which is known to extend the spectrum of activity to ceftazidime in addition to cefotaxime (14).
The patient was given a 2-week course of intravenous TMP/SMX (50 mg/10 mg/kg/d), oral doxycycline (4 mg/ kg/d), and intravenous ceftazidime (120 mg/kg/d), followed by a 6-month course of oral TMP/SMX (10 mg/50 mg/kg/d) and doxycycline (200 mg/d).
penumoniae ATCC700603 were as follows; cefpodoxime 9-16, ceftazidime 10-18, aztreonam 9-17 and cefotaxime 17-25.
A composition of matter patent which claims NXL 104 provides protection for the combination of NXL 104 with ceftaroline, ceftazidime and any other agents until 2022, subject to possible patent term extension.
NXL104 is being developed in combination with the cephalosporin antibiotic ceftazidime (CAZ-104) and is currently in two Phase II clinical trials in patients with complicated intra-abdominal infections (cIAIs) and patients with complicated urinary tract infections (cUTIs).
Of the 72 imipenem resistant isolates, 62 were positive by IPM-EDTA disc method, remaining 10 which did not show any increase in growth inhibition zone after addition of EDTA, may be belonging to IMP-1 category, as these were ceftazidime resistant also and positive by CAZ-MPA method.
AVYCAZ received a priority review and FDA approval was supported in part by the FDA's previous findings of efficacy and safety of ceftazidime for the treatment of cIAI and cUTI.
No resistance was noted for ceftazidime, meropenem, amoxicillin/clavulanic acid or doxycycline, but 12 (22.
NXL104, Novexel's broad spectrum non-beta-lactam class A and C beta-lactamase inhibitor which, in combination with the cephalosporin antibiotic ceftazidime, is currently in two Phase II trials for complicated urinary tract infections (cUTIs) and complicated intra abdominal infections(cIAIs).
The following antibiotics ([micro]g) were tested by the disk diffusion method, piperacillin (100), piperacillin/tazobactam (100/10), tic arcillin/clavulinic acid (75/10), ceftazidime (30), cefepime (30), cefoperazone (30), ceftriaxone (30), cefotaxime (30), amikacin (30), levofloxacin (5), ciprofloxacin (5) and imipenem (10) (Hi-Media Laboratories, Mumbai).