The mechanism of initial
cell fusion shown in As (III) experiments (and partially shown in chromium (VI) experiments) has not been well understood and thus has not been included in the models.
The researcher Pia Cosma and her team have used the
cell fusion mechanism to reprogram the neurons in the retina.
This is not surprising, because cycles of
cell fusion and chromosome segregation provide very strong selective advantages to molecular parasites, such as transposable elements and meiotic drive genes, which have clearly modified the sexual process to further their own interests.
By combining genetic, optogenetic, biochemical, live-imaging, synthetic and modeling approaches, this project will bring a molecular and conceptual understanding of
cell fusion.
The patent issued as United States Patent 5,916,771, entitled: Production of a Multimeric Protein by
Cell Fusion Method.
Nanog Promotes Transfer of Pluripotency After
Cell FusionCell fusion is one possible mechanism of regeneration, and our hypothesis is that Wnt/beta-catenin signalling activation triggers the reprogramming in vivo of spontaneously fused hybrids formed between adult stem cells and somatic cells, to regenerate damaged organs.
This study not only shows the power of stem
cell fusion technology, but also that cardiac regeneration is on the horizon.
The scientists have developed a simple but ingenious sorting method, which can boost the rate of successful
cell fusion from around 10 percent to about 50 percent.
PDI's role in breaking viral disulfide bonds, Brown adds, "may be an emerging motif for many viruses that enter cell membrances by
cell fusion.
