Now that cells from the sixty lines have been declared by the President to be simply a commodity, their value has already begun to be measured as- much in economic as in medical terms: there is a lot of money to be made here, and though these sixty cell lines
may now be studied with government money, they are not the property of our government.
ESI) has been at the forefront of advances in hES technology since 2000 and created the first cell bank of clinical-grade hES cell lines
derived following cGMP principles (Crook et al, 2007 The Generation of Six Clinical-Grade Human Embryonic Stem Cell Lines
Cell Stem Cell 1(5):490-4).
Developed in partnership with and backed by the Massachusetts Life Sciences Center, the Human Stem Cell Bank provides the biomedical research community with expertly derived and maintained human embryonic stem cell lines
for fundamental biological investigation and therapeutic applications.
Modulation of aromatase activity by growth factors in an androgen sensitive human prostate cancer cell line
The company said these are the first such cell lines
approved for federal funding that were derived under conditions designed to be compliant with current Good Manufacturing Practices (cGMP) for human clinical use.
As a result, HepaLife, using the patented PICM-19 cell line
, plans to develop proprietary in vitro toxicological and pre-clinical drug testing platforms that will more accurately determine the potential toxicity and metabolism of new pharmacological compounds in the liver.
The current study builds upon previous research showing that separate breast cancer cell lines
have distinctive responses to two different chemotherapeutic agents, doxorubicin (DOX) and 5-fluorouracil (5FU).
Scientists need and use stem cell lines
to conduct thousands of experiments.
Under the agreement, Vivalis grants the unnamed company the rights to assess the EB66 cell line
for the production of several animal health vaccine candidates.
The GloResponse[TM] NFAT-RE-luc2P HEK293 Cell Line
and CRE-luc2P HEK293 Cell Line
are designed for rapid and convenient analysis of cell signaling through the nuclear factor of activated T-cells (NFAT) pathway or cAMP response pathways via activation of a luciferase reporter gene.
According to the terms of the contract, Horizon has licensed to the Partner a novel cell line
engineering technology and non-exclusive rights to Horizon's proprietary Helitron transposon gene editing technology for an undisclosed financial consideration.
Furthermore, CHO cells have maintained their preeminence in the cell line
development field because of the on-going technological and genetic improvements, which over the past 15 years have resulted in shortening cell line
development timelines by 60-75%, boosting productivity by 1015X and allowing expression of increasingly complex, non-natural and difficult-to-express proteins.