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EURL ECVAM Recommendation on the cell transformation assays based on the Bhas 42 cell line.
However, the sT-Ag of MCPyV constructs altered to lack a functional PP2A binding domain still initiates cell transformation (29).
Recent reports about successful etoposide treatment in EBV-related hemophagocytosis are encouraging, but the mechanism includes etoposide interference of EBV nuclear antigen synthesis and cell transformation, which would not be expected to occur in our patient, whose EBV serology was negative.
In establishing that self-sustaining signal circuit, IL6 represses the action of microRNA-200c, which is responsible for holding down inflammation and cell transformation.
purpurea juice lyophilizate, a cell transformation assay with lyophilizate concentrations of up to 55[mu]g/mL was performed; no morphological transformations were induced in Syrian hamster embryo cells exposed to the lyophilizate.
This degradation of proteins by the cell's ubiquitin system controls cell growth and prevents malignant cell transformation.
using an innovative technology have discovered new molecular interactions in the process of stem cell transformation that they say will help regenerative medicine researchers better understand pluripotency.
MCF-10 F, estrogen receptor [alpha]-negative immortalized human breast epithelial cells acquire cell transformation properties similarly to those elicited by in vitro treatment with the carcinogen benzo[a]pyrene, when subject to treatment using 17-[beta]-estradiol (E2) (Russo et al.
Overexpression of FoxM1 potentiated cell proliferation, cell transformation, and migration/invasion of CRC cells via up-regulation of FoxM1 target genes MMP2 and MMP9 and protected these cells from thiostrepton-mediated antiproliferative effects.
The results show that the transcriptional regulation of STs is affected at early stages of cell transformation before the cancer development.
Fas-ligand (FasL), a member of the tumor necrosis superfamily, which is preferentially expressed in the basal layer of the skin epidermis, is a key surveillance molecule involved in the elimination of sunburn cells, but also in the prevention of cell transformation.
Northwest Hospital (Seattle, WA) has patented a method of identification of a novel role of Nr-CAM in cell transformation and aberrant cellular proliferation.