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Misoprostol, a prostaglandin E1 analogue was used in obstetrics because of its uterotonic and cervical ripening effects in different studies (7, 10).
Sublingual misoprostol for cervical ripening before diagnostic hysteroscopy in premenopausal women: a randomized, double blind, placebo-controlled trial.
All patients in both groups who did not go into spontaneous labour after 48 hours were categorised as 'failed labour induction' and together with the women with post-term pregnancies of [greater than or equal to]40 weeks and 10 days managed according to our departmental protocol of cervical ripening and labour induction (transcervical Foley catheter or intravaginal misoprostol) to ensure delivery before 42 weeks' gestation.
Uterine stimulation with oxytocin is often used in conjunction with cervical ripening agents and is the most common method of labor induction (Duff and Sinclair, 2000).
The company developed and manufactures Cervidil[R]/Propess[R], used in the obstetrics field for cervical ripening in the induction of labor.
The researchers, from the United States and Canada, are seeking to understand what role genetic variations, infection, fetal lung development and changes cervical ripening may play in triggering preterm labor.
Term labor is preceded by cervical ripening and effacement by several days.
Studies have been conducted for many years to develop new methods for cervical ripening and induction of labour.
Searle has not conducted research concerning the use of Cytotec[R] for cervical ripening prior to termination of pregnancy or for induction of labor, nor does Searle intend to study or support these uses.
Although the revised label does acknowledge extensive off-label use of misoprostol for cervical ripening or labour induction, and gives information about possible side effects, it does not acknowledge extensive off-label use for first and second trimester induced abortion.
Cervical Ripening Balloon Catheter Offers Safe Alternative to Ripening with Pharmaceuticals
Food and Drug Administration (FDA) supporting the use of the controlled release MVI as a treatment option for cervical ripening as part of the labor induction process.