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HIV-1 gp120 and chemokine activation of pyk2 and mitogen-activated protein kinases in primary macrophages mediated by calcium-dependent, pertussis toxin-insensitive chemokine receptor signaling.
The first co-receptor that HIV latches onto to enter the cell is called CC chemokine receptor 5 [CCR5].
The report provides comprehensive information on the C-X-C Chemokine Receptor Type 2 (CDw128b or GRO/MGSA Receptor or High Affinity Interleukin-8 Receptor B or IL-8 Receptor Type 2 or CD182 or CXCR2), targeted therapeutics, complete with analysis by indications, stage of development, mechanism of action (MoA), route of administration (RoA) and molecule type.
3] Nonstandard abbreviations: CSC, cancer stem cell; SDF-1, stromal-derived factor 1; CXCR4, C-X-C chemokine receptor type 4.
The results are expressed as a ratio of expression of chemokine or chemokine receptor to [beta]-actin expression.
Topics of the research and review papers include Nijmegen Breakage Syndrome, models of genetic and physiological heterogeneity, polymorphisms in CCR5 chemokine receptor genes, genetic anticipation, inheritance in mammal litter sizes in different populations, heritable and molecular genetic variation in mate choice and mating-related genes, osteogenesis imperfecta, tuberous sclerosis complex, and findings in Danon disease, a rare X-linked dominant disorder.
Some years ago we started evaluating the effect of highly active anti-retroviral therapy (HAART) at the level of CC chemokine production and chemokine receptor expression in a selected population of HIV-1 infected individuals showing a moderate immunodeficiency and mostly naive for antiretroviral therapy (19-22).
CXCR7 is a novel chemokine receptor whose function was discovered and characterized by ChemoCentryx.
Several years ago, researchers discovered that for the AIDS virus to infect an immune cell, HIV must grab on to a cell-surface protein called a chemokine receptor.
Several chemokine receptor molecules have also been studied including the CCR2 and CXCR4 molecules.
Global Markets Direct's, 'C-C Chemokine Receptor Type 4 (C-C CKR-4 or K5-5 or CD194 or CCR4) - Pipeline Review, H1 2016', provides in depth analysis on C-C Chemokine Receptor Type 4 (C-C CKR-4 or K5-5 or CD194 or CCR4) targeted pipeline therapeutics.