Johnson explained that happens as flavonoids can act as antioxidants; one of the ways that chemotherapeutic drugs
kill cells is based on their pro-oxidant activity, meaning that flavonoids and chemotherapeutic drugs
may compete with each other when they're introduced at the same time.
Also, the Bcl-w and E2F6 stable expressing WPE-1 NA22 cell lines showed high resistance to various chemotherapeutic drugs
Grothey said, when toxic chemotherapeutic drugs
can be phased out entirely, replaced by combinations of biologics tailored to individual tumors.
Researchers at UCLA's California NanoSystems Institute and Jonsson Comprehensive Cancer Center also showed that MSNs accumulate almost exclusively in tumors after administration and that the nanoparticles are excreted from the body after they have delivered their chemotherapeutic drugs
High-dose intravenous vitamin C is a common form of alternative and complementary therapy for patients receiving chemotherapeutic drugs
, and is believed to help bring about tumour cell death.
The presence of LRP, more so than that of either Pgp or MRP, provided the most accurate indication of whether the cells were susceptible to chemotherapeutic drugs
, the researchers report in the Jan.
FDA-approved, 5-FU is one of the world's most widely used chemotherapeutic drugs
Because almost all the chemotherapeutic drugs
kill through very similar mechanisms to hypoxia, we may need to totally change the type of drugs we use," says Lowe.
In phase 2 studies, Ceflatonin([R]) has demonstrated clinical activity in patients with CML, both as a single agent and in combination with other chemotherapeutic drugs
Nabel, a Howard Hughes Medical Institute researcher at the University of Michigan Medical Center in Ann Arbor, and his colleagues turned to liposomes, artificially produced fat particles that have long been used to ferry toxic chemotherapeutic drugs
into human cells.
Afterwards, patients received an initial blast of several different types of chemotherapeutic drugs
, as well as radiation therapy.
Black pioneered research on designing ways to open the blood-brain barrier, enabling chemotherapeutic drugs
to be delivered directly into the tumor.