The patented technology affords pinpoint accuracy in delivering a chemotherapeutic drug
to targeted tumor cells, reducing drug-related toxicity without sacrificing therapeutic impact.
Jodee Johnson, a doctoral student in de Mejia's lab who has since graduated, said that the trick seemed to be using the flavonoids as a pre-treatment instead of applying them and the chemotherapeutic drug
A presentation from the 44th annual meeting of the American Society of Clinical Oncology revealed that calcium and magnesium administered intravenously to patients undergoing chemotherapy results in a significant reduction in neurotoxicity, a common side effect of chemotherapeutic drugs
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Washington, August 2 ( ANI ): Researchers have discovered a mutant form of the gene, Chk1, that when expressed in cancer cells, permanently stopped their proliferation and caused cell death without the addition of any chemotherapeutic drugs
Several of these genes endow tumor cells with greater resistance to chemotherapeutic drugs
, while others are oncogenes, mutated genes that encourage a cell's proliferation or growth.
Somanta's lead drug candidate is Alchemix, a chloroethylaminoanthraquinone, a multi-target inhibitor that overcomes chemotherapeutic drug
resistance by binding to DNA in tumor cells.
Cytoxan is the most commonly used chemotherapeutic drug
and is often used in the treatment of breast cancer and non-Hodgkins lymphoma.
There are several chemotherapeutic drugs
available for treatment if the cancer is diagnosed at an early (non-malignant) stage.
In the late-stage study, patients received Nexavar in combination with chemotherapeutic drugs
carboplatin and paclitaxel.
Abnormal DNA methylation is often found on DNA from cancerous cells and is believed to impact a tumor's sensitivity to chemotherapeutic drugs
This linkage is important for a new field of research and medicine known as chronotherapy, which aims to coordinate the delivery of chemotherapeutic drugs
with the circadian and cell cycles to maximize drug efficacy while minimizing side effects.