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Synergistic activation of the human choline acetyltransferase gene by c-Myb and C/EBPb.
Parallel regional quantification of choline acetyltransferase and cholinesterase activity in the central nervous system of an invertebrate (Sepia officinalis).
To answer these questions, we evaluated PC12 cells in the undifferentiated state (CPF without NGF), at the initiation of differentiation (inclusion of CPF simultaneously with the addition of NGF), and at mid-differentiation (CPF added after several days of NGF pretreatment), evaluating cell viability, DNA synthesis associated with cell replication, and enzymatic markers that characterize the cholinergic or catecholaminergic phenotype: choline acetyltransferase (CHAT) and tyrosine hydroxylase (TH), respectively.
For example, scientists have identified a striking reduction--as much as 90 percent--in a particular brain enzyme (choline acetyltransferase) that is involved in the passage of nerve signals.
The most important changes observed are a decrease in the acetylcholine neurotransmitter, as well in levels of the respective enzymes that synthesize and degrade acetylcholine, choline acetyltransferase and acetylcholinesterase (AChE) (Perry et al.
The concentration of ACh exhibits distinct peaks during early cleavage divisions, but the major, sustained increases occur after the beginning of gastrulation, in tandem with transcription of zygotic genes and attendant rises in choline acetyltransferase, the enzyme that synthesizes ACh (Buznikov et al.