Assay

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ASSAY. A chemical examination of metals, by which the quantity of valuable or precious metal contained in any mineral or metallic mixture is ascertained. 2. By the acts of Congress of March 3, 1823, 3 Story's L. U. S. 1924; of June 25, 1834, 4 Shars. cont. Story's L. U. S. 2373; and of June 28, 1834, Id. 2377, it is made the duty of the secretary of the treasury to cause assays to be made at the mint of the United States, of certain coins made current by the said acts, and to make report of the result thereof to congress.

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Furthermore, given that LAC interferes with in vitro clotting-based assays, esoteric chromogenic assays should be used in this setting to measure factor VIII activity and the strength of the factor VIII inhibitor, which can provide essential guidance regarding patient management.

A 77-year-old man with a prolonged activated partial thromboplastin time

Qualitative PT (a) PT (a) assessment of NO AC levels Quantitative Chromogenic anti-factor Chromogenic assessment of NO AC Xac anti-factor Xa (c) levels Abbreviations: aPTT, activated partial thromboplastin time; dTT, dilute thrombin time; ECA, ecarin chromogenic assay; ECT, ecarin clotting time; FDA, US Food and Drug Administration; INR, international normalized ratio; N/A, not applicable; NOAC, novel oral anticoagulant; PT, prothrombin time; TT, thrombin time.

Novel Oral Anticoagulants: Efficacy, Laboratory Measurement, and Approaches to Emergent Reversal

This method uses titration to a given concentration of heparin using either the protamine sulfate neutralization technique or a factor Xa inhibition chromogenic assay. The CAP conference XXXI on lab monitoring of UFH therapy recommends that the most appropriate method for determination of the heparin therapeutic range is through direct comparison of the APTT assay with heparin concentrations from samples of stabilized patients receiving heparin.

Selecting an APTT reagent

However, such fragments may still possess significant anti-Xa activity and thus be detected via the chromogenic assay.

Improved protamine-sensitive membrane electrode for monitoring heparin concentrations in whole blood via protamine titration

In addition to ProC Global, samples were assayed for FV Leiden (Coatest APC Resistence, Chromogenics, 1+4 dilution of samples in FV-deficient plasma), protein C activity (chromogenic assay, Boehringer Mannheim), and protein 5 activity (clotting test, Boehringer Mannheim).

ProC[R] global: the first functional screening assay for the complete protein C pathway

(76,82) Nowadays, three major methods are used for the measurement of factor VIII, namely one-stage methods, classical two-stage assay and chromogenic assays. (81)

Clinical and laboratory approaches to hemophilia A

(28) As an alternative to clotting based tests, the chromogenic assays are specific, but currently lack widespread availability.

Direct thrombin inhibitors: clinical uses, mechanism of action, and laboratory measurement